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Because coronavirus attacks the rapidly growing cells of the intestinal lining, gastrointestinal symptoms may be present. Vaccines come in two forms: modified live formulas that include a weakened form of the disease and killed or inactivated formulas that have an additional substance called an adjuvant added to boost the immune response. The virus first emerged in the United States, Europe, Asia and Australia in 1978, when a virus similar to feline panleukopenia virus crossed over from cats to cause a new type of disease among domestic dogs. Others may start with limping, swelling in the lymph nodes, and fever, and can progress to loss of appetite and lethargy.